Oscar-nominated actor Eric Dane is set to make a poignant guest appearance in Season 2, Episode 9 of NBC’s medical drama Brilliant Minds. Dane will portray Matthew, a heroic firefighter struggling to come to terms with his ALS diagnosis and deciding how to share the news with his family. The episode is scheduled to air on November 24, 2025, at 10/9c, with streaming available on Peacock the following day. (People)
A Personal Connection
Dane’s portrayal is deeply informed by his own experience with ALS, which he publicly revealed in April 2025. His personal journey brings authenticity and depth to the character, highlighting the emotional and physical challenges of living with the disease.
Since his diagnosis, Dane has been an active advocate for ALS awareness and research, participating in public discussions and supporting initiatives to improve access to treatments and clinical trials. His guest role on Brilliant Minds continues this advocacy, raising awareness through storytelling. (EW)
About Brilliant Minds
The series stars Zachary Quinto as Dr. Oliver Wolf, a neurologist at Bronx General Hospital who uses unconventional methods to diagnose and treat complex neurological conditions. Inspired by the works of renowned neurologist Dr. Oliver Sacks, the show explores extraordinary medical cases and the human stories behind them. (People)
Dane’s episode promises to be one of the most emotional and impactful installments of the season, providing a raw and authentic look at the struggles faced by ALS patients and their families.
Why This Matters
By bringing his own experiences to the role, Dane not only delivers a compelling performance but also continues to shed light on the importance of research, awareness, and support for those living with ALS. The episode is expected to resonate strongly with viewers, inspiring empathy and understanding while maintaining the drama and suspense that Brilliant Minds is known for.
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